Palmitoyl Tripeptide-38
INCI: Palmitoyl Tripeptide-38
Lipidated signal peptide (Matrixyl synthe’6) marketed to upregulate collagen, fibronectin, hyaluronic acid, and laminin 5. Modest wrinkle reduction in manufacturer studies.
ComedogenicDescribes any ingredient, cosmetic, or skincare product that tends to clog pores. Scored 0 (non-comedogenic) to 5 (highly likely to clog pores).
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IrritancyRefers to the state or quality of being irritating, provoking annoyance, or causing physical discomfort. Scored 0 (well tolerated) to 5 (likely to irritate sensitive skin).
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EWGThe Environmental Working Group operates the EWG Skin Deep® Cosmetics Database, which evaluates the safety of tens of thousands of personal care products. Scored 0–10 based on hazard level: 0–2 low hazard, 3–6 moderate, 7–10 high.
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Functions
peptide, signal-peptide
Functions in a formula
- peptide
- signal-peptide
Suitable for skin types
- Mature
- Normal
- Dry
Also listed as
Matrixyl synthe’6
Our matcher recognises all of these names automatically.
This page is continuously reviewed. Last updated 7/1/2026.
Informational only - not medical advice. See methodology.